Antimicrobial activity of menthol modified nanodiamond particles |
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| Affiliation: | 1. Institut de Recherche Interdisciplinaire (IRI, USR CNRS 3078), Université Lille 1, Parc de la Haute Borne, 50 Avenue de Halley, BP 70478, 59658 Villeneuve d''Ascq, France;2. Taras Shevchenko University, 60 Vladimirskaya Str., Kiev, Ukraine;3. School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK;4. Iasi Plasma Advanced Research Center (IPARC), Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 11, Iasi 700506, Romania;5. Chemistry Department, Pontifical Catholic University of Rio de Janeiro, Rua Marques de Sao Vicente, 225-Gavea, Rio de Janeiro 22451-900, Brazil;1. Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595;2. Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado;3. Immunetics, Inc., Boston, MA 02210;4. Division of Emergency Medicine, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115;5. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA;1. Faculty of Chemical Engineering, Sahand University of Technology, Tabriz, Iran;2. Membrane Technology Research Center, Sahand University of Technology, Tabriz, Iran;3. Department of Biological Science and Technology, Malek-Ashtar University of Technology, Tehran, Iran;1. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal;2. Departments of Pediatrics, Columbia University Medical Center, 701 W. 168th, New York, NY, USA |
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| Abstract: | Advances in nanotechnology have seen the development of several microbiocidal nanoparticles displaying activity against biofilms. These applications benefit from one or more combinations of the nanoparticle properties. Nanoparticles may indeed concentrate drugs on their surface resulting in polyvalent effects and improved efficacy to fight against bacteria. Nanodiamonds (NDs) are among the most promising new materials for biomedical applications. We elucidate in this paper the effect of menthol modified nanodiamond (ND-menthol) particles on bacterial viability against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. We show that while ND-menthol particles are non-toxic to both pathogens, they show significant antibiofilm activity. The presence of ND-menthol particles reduces biofilm formation more efficiently than free menthol, unmodified oxidized NDs and ampicillin, a commonly used antibiotic. Our findings might be thus a step forward towards the development of alternative non antibiotic based strategies targeting bacterial infections. |
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