In vitro biocompatibility assessment of a novel PRGD/PDLLA/NGF composite material |
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| Authors: | Yixia?Yin Qiongjiao?Yan Yuhua?Yan Xiaoming?Chen Email author" target="_blank">Shipu?LiEmail author |
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| Affiliation: | YIN Yixia,YAN Qiongjiao,YAN Yuhua,CHEN Xiaoming,LI Shipu (Biomaterials and Engineering Research Center,Wuhan University of Technology,Wuhan 430070,China ) |
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| Abstract: | The objective of this study was to evaluate the degradability and biocompatibility of a novel composite materials which was
grafted with RGD and immobilized with NGF(PRGD/PDLLA/NGF). The releasing of NGF, the biodegradability and cell-biocompatibility
of PRGD/PDLLA/NGF membrane were evaluated in vitro. The experimental results showed that the NGF release process was prolonged
over 30 days. Furthermore, the PRGD/PDLLA/NGF showed a better hydrophilicity, better biodegradation properties and cells affinity
than PDLLA, which means a good support to adhesion and proliferate of Schwann cells. Therefore, the novel composite material
holds considerable promise as scaffolds in nerve tissue engineering. |
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| Keywords: | PRGD/PDLLA/NGF schwann cells biocompatibility scaffold |
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