| 维生素C磷酸酯的工艺优化研究 |
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| 引用本文： | 薛颖,杨亮茹,肖咏梅,毛璞,范丹鸣,屈凌波.维生素C磷酸酯的工艺优化研究[J].辽宁化工,2010,39(10):1003-1006,1009. |
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| 作者姓名： | 薛颖 杨亮茹 肖咏梅 毛璞 范丹鸣 屈凌波 |
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| 作者单位： | 河南工业大学化学化工学院,河南郑州450001 |
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| 摘 要： | 通过L-抗坏血酸与丙酮反应生成中间产物5,6-O-异丙叉-L-抗坏血酸(IPAA),再与三氯氧磷在水和吡啶混合体系中进行磷酰化反应,得L-抗坏血酸-2-磷酸酯镁(AP-Mg)。利用正交试验法得到制备L-抗坏血酸-2-磷酸酯镁的最佳工艺条件为:POCl3与IPAA的摩尔比为1.8∶1,吡啶浓度2.6 mol/L,pH=12.5时,产率86.75%,纯度92.30%。
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| 关 键 词： | L-抗坏血酸-2-磷酸酯镁 维生素C 正交试验法 |
Study on Optimal Preparation Process of L-Ascorbic Acid-2-Phosphate |
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| XUE Ying,YANG Liang-ru,XIAOYong-mei,MAO Pu,FAN Dan-ming,QV Ling-bo.Study on Optimal Preparation Process of L-Ascorbic Acid-2-Phosphate[J].Liaoning Chemical Industry,2010,39(10):1003-1006,1009. |
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| Authors: | XUE Ying YANG Liang-ru XIAOYong-mei MAO Pu FAN Dan-ming QV Ling-bo |
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| Affiliation: | XUE Ying,YANG Liang-ru,XIAOYong-mei,MAO Pu,FAN Dan-ming,QV Ling-bo(School of Chemistry and Chemical Engineering,Henan University of Technology,zhengzhou 450001,China) |
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| Abstract: | L-ascorbic acid reacted with acetone to prepare 5,6-O-isopropylidene-L-ascorbic acid（IPAA）,then it phosphorylated with phosphorus oxychloride in mixed system of water and pyridine to synthesize magnesium L-ascorbate-2-phosphate.By orthogonal test,the best process conditions of preparing magnesium L-ascorbate-2-phosphate were gained as follows：molar ratio of IPAA and phosphorus oxychloride was 1∶1.8,pyridine concentrations was 2.6 mol/L,pH was 12.5.Under above conditions,yield and purity of the product were 86.7% and 92.3% respectively. |
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| Keywords: | Magnesium L - ascorbic acid 2 - phosphate L - ascorbic acid Orthogonal test |
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