Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex |
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| Authors: | G Bompart I Tack E Marin Casta?o JB Pesquero JP Girolami JL Bascands |
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| Affiliation: | INSERM U388 Institut Louis Bugnard, CHU Rangueil, Toulouse, France. |
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| Abstract: | The effect of subcutaneous injection of cyclosporine (20 mg/kg/day for 3 days) on the expression of kallikrein (Kal) and bradykinin 2 receptor (BK2) mRNA in the rat renal cortex was examined. CsA decreased significantly Kal and BK2 mRNA expression in the kidney cortex. These results indicate that the kallikrein-kinin system may participate in the genesis or the aggravation of the renal haemodynamic effect induced by long term administration of CsA. |
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