Systematic study of Nd~(3+) on structural properties of ZnO nanocomposite for biomedical applications; in-vitro biocompatibility,bioactivity, photoluminescence and antioxidant properties |
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| Affiliation: | 1. Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz 5156917511, Iran;2. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran;3. Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, Tabriz 5156917511, Iran;1. School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou 450001, China;2. Laboratory of Special Metallurgy and Process Engineering, School of Metallurgy, Northeastern University, Shenyang 110819, China;1. “Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, 41A, Iaşi 700487, Romania;2. “Alexandru Ioan Cuza” University, Department of Chemistry, 11, Carol I Boulevard, 700506 Iasi, Romania;3. Center of Materials Technology and Laser, School of Electrical Engineering, Technological Educational Institute of Crete, Heraklion, Greece;4. National Institute for Research and Development in Microtechnologies (IMT-Bucharest), Bucharest, Romania;1. National Institute of Materials Physics, P.O. Box MG-7, Bucharest-Magurele 077125, Romania;2. Politehnica University of Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, Romania;1. Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, 650500, PR China;2. School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China;3. Faculty of Science, Kunming University of Science and Technology, Kunming, 650500, PR China;4. Faculty of Metallurgy and Energy Engineering, Kunming University of Science and Technology, Kunming, 650500, PR China;1. “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania;2. Faculty for Industrial Chemistry and Environmental Engineering, University “Politehnica” of Timisoara, Piata Victoria, 30006 Timisoara, Romania;3. National Institute for Lasers, Plasma and Radiation Physics, Atomistilor 409, PO-Box MG-36, 077125 Magurele, Romania;4. National Institute for Research and Development in Electrical Engineering, ICPE-CA, Advanced Research, Splaiul Unirii 313, 030138 Bucharest, Romania;5. University of Bucharest, Faculty of Biology, Microbiology Department, 1-3 Portocalilor Way and The Research Institute of the University of Bucharest, ICUB, Spl. Independentei 91-95, Bucharest, Romania;6. “St. S. Nicolau” Institute of Virology, 285, Sos. Mihai Bravu, Bucharest 030304, Romania |
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| Abstract: | Owing to the inconformity in ionic radius between Nd~(3+) and Zn~(2+), the successful incorporation of Nd~(3+) ion into the ZnO nanocrystals still remains a great challenge. In the present study various doping ratios containing 1 wt%, 5 wt%, 7 wt% and 10 wt% of Nd~(3+) doped ZnO nanoparticles(Nd/ZnO NPs) were synthesized in which a bio-layer caped the NPs. SEM/EDX analysis was performed on the ZnO and Nd/ZnO NPs. In addition, the as-synthesized NPs were characterized using X-ray diffraction(XRD), dynamic light scattering(DLS), differential reflectance spectroscopy(DRS) and photoluminescence(PL) spectroscopy.The average size of Nd(5 wt%)/ZnO NPs was in the range of 6.22 and 15 e18 nm based on XRD and SEM techniques, respectively. The measured band gap values for pure ZnO and Nd/ZnO NCs with doping ratios of 1 wt%, 5 wt%, 7 wt% and 9 wt% were equal to 3.46, 3.26, 3.05, 3.25 and 3.29, respectively. After inhalation, nanoparticles first interact with lung surfactant system and accordingly their toxic effects will appear on lungs cells such as A549 cell line. The effect of Nd/ZnO NPs to interact by human A549 cell line was evaluated by means of cell viability test. According to cell viability test the concentrations of 0.3 and 0.5 mg/mL of Nd/ZnO NPs induce a low toxicity. The present study shows that these toxic effects of Nd/ZnO NPs can be rectified by capping its surface via the addition of a bio-layer around particles in order to prevent them from interacting A549 cell line. |
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| Keywords: | Neodymium Rare earth elements Cell viability test Nanostructures |
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