G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling |
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Authors: | Anjum Riaz Ying Huang Staffan Johansson |
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Affiliation: | 1.Institute of Biochemistry and Biotechnology, University of the Punjab, 54590 Lahore, Pakistan; ;2.Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, 75123 Uppsala, Sweden; |
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Abstract: | A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to these ligands and carry out their biological functions by activating G-proteins coupled to a large family of cell-surface receptors. This review aims to highlight salient features of cell signaling by one class of these receptors, known as lysophosphatidic acid (LPA) receptors, in the context of phosphatidylinositol 3-kinase (PI3K)–AKT pathway activation. LPA moieties efficiently activate AKT phosphorylation and activation in a multitude of cell types. The interplay between LPA, its receptors, the associated Gαi/o subunits, PI3K and AKT contributes to the regulation of cell survival, migration, proliferation and confers chemotherapy-resistance in certain cancers. However, detailed information on the regulation of PI3K–AKT signals induced by LPA receptors is missing from the literature. Here, some urgent issues for investigation are highlighted. |
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Keywords: | G-protein coupled receptors (GPCR) lysophosphatidic acid (LPA) PI3K AKT |
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