羟基磷灰石/TiO2复合涂层在模拟脑脊液中生物相容性（英文）

应用阳极氧化法在Ti-6Al-4V钛合金（TC4）表面制备了多孔TiO2涂层,在TiO2涂层表面电沉积制备了羟基磷灰石（hydroxyapatite,HA）/TiO2复合涂层,用实验用人工脑脊液（artificial cerebrospinal fluid,ACSF）体液模拟人体的脑脊液,以TC4和TiO2涂层为对比,研究了HA/TiO2涂层在浸泡过程中发生的物理化学变化,考察了HA/TiO2复合涂层抑制钛合金中元素Al和V的析出情况。结果表明：3种样品随浸泡时间的延长遵循的生长规律为：HA成核→HA晶粒长大→HA晶粒相互团簇形成一体→涂层逐渐扩大覆盖到整个基体表面;TC4,TiO2以及HA/TiO2涂层在ACSF中都能够诱导HA的生成,表现出了良好的生物活性。检测浸泡后溶液中Al和V的浓度可知,阳极氧化法制备的TiO2涂层对于Al,V元素的析出起到了一定的抑制作用,能够进一步提高钛合金的生物相容性。

Abstract：

Porous TiO2 coating was prepared on Ti-6Al-4V titanium alloy （TC4） substrate by the potentiostatic anodic oxidation method,and hydroxyapatite （HA） coating was prepared on the surface of TiO2 coating by the electrodeposition method to form HA/TiO2 composite coating. By using artificial cerebrospinal fluid （ACSF） to simulate human cerebrospinal fluid,the physicochemical changes of the HA/TiO2 coatings when soaked in ACSF were studied and compared with TC4 and TiO2 coating. Its inhabitation effects on Al and V were also studied. The results show that these three samples follow such a growth pattern：HA nucleation forma-tion,crystal growth,agglomeration,coatings formation. The bioactivity of TC4,TiO2 coating and TiO2/HA composite coating can be induced by the formation of HA in ACSF. According to the concentration of Al and V in ACSF,the TiO2 coating formed by anodic oxidation could inhibit the element precipitation more or less,and enhance the biocompatibility of titanium alloy.

BIO-COMPATIBILITY OF HYDROXYAPATITE/TiO2 COMPOSITE COATINGS IN ARTIFICIAL CEREBROSPINAL FLUID

Porous TiO2 coating was prepared on Ti-6Al-4V titanium alloy （TC4） substrate by the potentiostatic anodic oxidation method,and hydroxyapatite （HA） coating was prepared on the surface of TiO2 coating by the electrodeposition method to form HA/TiO2 composite coating. By using artificial cerebrospinal fluid （ACSF） to simulate human cerebrospinal fluid,the physicochemical changes of the HA/TiO2 coatings when soaked in ACSF were studied and compared with TC4 and TiO2 coating. Its inhabitation effects on Al and V were also studied. The results show that these three samples follow such a growth pattern：HA nucleation forma-tion,crystal growth,agglomeration,coatings formation. The bioactivity of TC4,TiO2 coating and TiO2/HA composite coating can be induced by the formation of HA in ACSF. According to the concentration of Al and V in ACSF,the TiO2 coating formed by anodic oxidation could inhibit the element precipitation more or less,and enhance the biocompatibility of titanium alloy.