Influence of Alcohol on the Release of Tramadol from 24-h Controlled-Release Formulations During In Vitro Dissolution Experiments |
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| Authors: | M. J. Traynor M. B. Brown A. Pannala P. Beck G. P. Martin |
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| Affiliation: | 1. School of Pharmacy, University of Hertfordshire, Hatfield, Hertfordshire, UK;2. MedPharm Ltd., Surrey Research Park, Guildford, UK;3. Pharmaceutical Science Division, King's College London, London, UK |
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| Abstract: | Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram® ER tablets and T-long® capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural? extended-release tablets in the presence of alcohol. |
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| Keywords: | tramadol controlled release alcohol in vitro |
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