к-卡拉胶的氧化降解(英文)

к-卡拉胶有着良好的药理和生理活性 ,但是由于分子量大 ,溶解性差使它的应用受到很大的限制。研究了在中性和酸性条件下利用 H2 O2 对卡拉胶进行降解来制备低分子量的卡拉胶时 H2 O2 浓度、卡拉胶浓度、反应温度和时间对反应的影响。发现提高 H2 O2浓度、降低卡拉胶浓度、提高反应温度有利于卡拉胶分子量的降低。通过粘度法测量了卡拉胶的平均分子量在 1 0 0 0～ 1 0 0 0 0 ,并发现它的溶解性大大提高了。利用 IR和13 C-NMR研究了降解前后卡拉胶的结构变化

Oxidative Degradation of κ-Carrageenan

carrageenan has helpful physiological and pharmacological activities, but its applications on medicine are limited due to its high molecular weight and bad solubility. The κ-carrageenan low molecular weight (LMW) by hydrogen peroxide (H 2O 2) was produced firstly in the neutral and acid conditions. The effects of concentration of hydrogen peroxide, the ratio of reactants, reaction temperature and time were discussed. The average molecular weight (AMW) of κ-carrageenan was measured by viscosity method. The AMW varied from 1000 to 10000 and solubility was increased greatly. The chemical structure and the mechanism of degradation were studied by 13 C-NMR and IR spectra.