| 螺虫乙酯的合成 |
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| 引用本文： | 师文娟,廖道华,杨芳,刘少春,杜梦.螺虫乙酯的合成[J].农药,2010,49(4). |
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| 作者姓名： | 师文娟 廖道华 杨芳 刘少春 杜梦 |
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| 作者单位： | 华东理工大学药学院,上海,200237 |
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| 摘 要： | cis-8-甲氧基-1,3-二氮杂螺4.5]癸-2,4-二酮水解得到含有cis-4-甲氧基环己基-1-氨基甲酸的混合物,对该混合物进行纯化处理得到cis-4-甲氧基环己基-1-氨基甲酸.cis-4-甲氧基环己基-1-氨基甲酸在饱和氯化氢的甲醇溶液中酯化,接着酰化,环合,最后与氯甲酸乙酯发生取代反应,生成目标产物螺虫乙酯.反应总收率72%,含量97.5%(HPLC,面积归一法),产物经1H NMR、MS进行了表征.
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| 关 键 词： | 杀虫剂 螺虫乙酯 (4-甲氧基)-环己基-氨基甲酸甲酯 2 5-二甲基苯乙酰氯 合成 |
Synthesis of Spirotetramat |
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| SHI Wen-juan,LIAO Dao-hua,YANG Fang,LIU Shao-chun,DU Meng.Synthesis of Spirotetramat[J].Pesticides,2010,49(4). |
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| Authors: | SHI Wen-juan LIAO Dao-hua YANG Fang LIU Shao-chun DU Meng |
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| Affiliation: | Pharmacy School/a>;East China University of Science and Technology/a>;Shanghai 200237/a>;China |
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| Abstract: | cis-8-Methoxy-1,3-diazaspiro4.5]decane-2,4-dione was hydrolyzed to a mixture containing cis-4-methoxylcyclohexane-1-amino-carboxylic acid. The mixture was purified to obtain cis-4-methoxylcyclohexane-1-amino-carboxylic acid. cis-4-Methoxyl-cyclohexane-1-amino-carboxylic acid methyl ester was synthesized by esterification of cis-4-methoxylcyclohexane-1-amino-carboxylic acid in saturated solution of hydrogen chloride in methanol. Starting from cis-4-methoxylcyclohexane-1-amino-carboxylic acid methyl ester, s... |
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| Keywords: | pestcide spirotetramat cis-4-methoxyl-cyclohexane-1-amino-carboxylic methyl ester 2 5-dimethylphenylacetyl chloride synthesis |
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