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| 4-(N,N-二乙基胺基)苯乙酮的制备 | |
| 引用本文： | 李韶辉,王占奇,仲锡军,刘鑫勤,员国良,郭民生. 4-(N,N-二乙基胺基)苯乙酮的制备[J]. 精细化工, 2004, 21(Z1): 79-81 |
| 作者姓名： | 李韶辉 王占奇 仲锡军 刘鑫勤 员国良 郭民生 |
| 作者单位： | 石家庄实力克液晶材料有限公司,河北,石家庄,050061 |
| 摘 要： | 介绍了一种制备4 (N,N 二乙基胺基)苯乙酮的方法,该方法以N,N 二乙基苯胺为原料经Vilsmeier反应制得4 (N,N 二乙基胺基)苯甲醛,再与盐酸羟胺成肟脱水得到4 (N,N 二乙基胺基)苯甲腈,最后与氯甲烷格氏试剂反应水解后而得。经过工艺改进,反应各步收率分别达到80%、90%、85%,合成总收率达到了60%。 |
| 关 键 词： | 4-(N,N-二乙基胺基)苯乙酮 N,N-二乙基苯胺 4-(N,N-二乙基胺基)苯甲醛 4-(N,N-二乙基胺基)苯甲腈 Vilsmeier反应 格氏反应 |
| 文章编号： | 1003-5214(2004)S0-0079-03 |
| 修稿时间： | 2004-06-07 |
Preparation of 4-(N,N-Diethylamino)acetophenone |
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| LI Shao-hui,WANG Zhan-qi,ZHONG Xi-jun,LIU Xin-qin,YUAN Guo-liang,GUO Min-sheng. Preparation of 4-(N,N-Diethylamino)acetophenone[J]. Fine Chemicals, 2004, 21(Z1): 79-81 | |
| Authors: | LI Shao-hui WANG Zhan-qi ZHONG Xi-jun LIU Xin-qin YUAN Guo-liang GUO Min-sheng |
| Abstract: | A convenient synthesis method of 4-(N,N-diethylamino)acetophenone is described.Firstly,4-(N,N-diethylamino)benzaldehyde was prepared in 80% yield through Vilsmeier reaction of N,N-diethylaniline.Then this aldehyde was converted to 4-(N,N-diethylamino)benzonitrile in 90% yield through oximation and dehydration.Finally,4-(N,N-diethylamino)acetophenone was prepared in 85% yield through Grignard reaction of CH_3MgCl with 4-(N,N-diethylamino)benzonitrile.The total yield of preparation amounted to 60%. |
| Keywords: | 4-(N N-diethylamino)acetophenone N N-diethylaniline 4-(N N-diethylamino)benzaldehyde 4-(N N-diethylamino)benzonitrile Vilsmeier reaction Grignard reaction |
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