| 温敏聚N-异丙基丙烯酰胺的载药和释药性能研究 |
| |
| 引用本文： | 刘少华,田博士,詹秀环,杜晓迪,张修平,王旗,张吉苹,姚新建,王子云.温敏聚N-异丙基丙烯酰胺的载药和释药性能研究[J].化学试剂,2012,34(2):157-161. |
| |
| 作者姓名： | 刘少华 田博士 詹秀环 杜晓迪 张修平 王旗 张吉苹 姚新建 王子云 |
| |
| 作者单位： | 周口师范学院化学系,河南周口,466000 |
| |
| 基金项目： | 河南省教育厅自然科学研究资助项目，周口师范学院青年科研基金，周口师范学院大学生创新基金 |
| |
| 摘 要： | 以对乙酰氨基酚为模型药物分子,温敏水凝胶聚N-异丙基丙烯酰胺(PNIPAAm)为载体,研究了药物在凝胶上的负载和在不同温度(25和37℃)下磷酸盐缓冲溶液(pH 7.4)中的释放行为.结果表明,对乙酰氨基酚的负载量约为35wt％,并且与载体PNIPAAm存在氢键作用.药物在磷酸盐缓冲溶液中的体外模拟释放结果显示,当温度(37℃)高于凝胶的LCST时,对乙酰氨基酚释放的较慢；当温度(25℃)低于其LCST时,释放的较快.因此,可通过环境温度的改变达到APAP在载体PNIPAAm上控制释放的目的.
|
| 关 键 词： | 温敏 聚N-异丙基丙烯酰胺(PNIPAAm) 对乙酰氨基酚(APAP) 氢键 控制释放 |
Study on drug loading and release from thermo-sensitive poly ( N-isopropylacrylamide ) |
| |
| LIU Shao-hua
,
TIAN Bo-shi
,
ZHAN Xiu-huan
,
DU Xiao-di
,
ZHANG Xiu-ping
,
WANG Qi
,
ZHANG Ji-ping
,
YAO Xin-jian
,
WANG Zi-yun.Study on drug loading and release from thermo-sensitive poly ( N-isopropylacrylamide )[J].Chemical Reagents,2012,34(2):157-161. |
| |
| Authors: | LIU Shao-hua TIAN Bo-shi ZHAN Xiu-huan DU Xiao-di ZHANG Xiu-ping WANG Qi ZHANG Ji-ping YAO Xin-jian WANG Zi-yun |
| |
| Affiliation: | (Department of Chemistry,Zhoukou Normal University,Zhoukou 466000,China) |
| |
| Abstract: | Used acetaminophen(APAP) as model drug and thermo-sensitive gel poly(N-isopropylacrylamide)(PNIP-AAm) as carrier,the drug loading and release behavior was investigated in phosphate buffer solution(pH 7.4) at different temperatures(25 and 37 ℃).It was found that the loading amount of APAP was about 35 wt% and interacted with PNIPAAm by intermolecular hydrogen bond.The results of drug release showed that APAP released slower at 37 ℃(above LCST) than that at 25 ℃(bellow LCST) in PBS.Therefore,the release of APAP from the thermo-sensitive PNIPAAm hydrogel could be controlled by changing the temperature around LCST. |
| |
| Keywords: | thermo-sensitive poly(N-isopropylacrylamide) acetaminophen(APAP) hydrogen bond controlled release |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
