Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells |
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| Authors: | Ewelina Szliszka Zenon P Czuba Bogdan Mazur Lukasz Sedek Andrzej Paradysz Wojciech Krol |
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| Affiliation: | 1. Chair and Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41 808 Zabrze, Poland; E-Mails: (E.S.); (Z.P.C.); (B.M.);2. Chair and Department of Pediatric Hematology and Oncology, Medical University of Silesia in Katowice, 3-go Maja 13, 41 800 Zabrze, Poland; E-Mail: (L.S.);3. Chair and Department of Urology, Medical University of Silesia in Katowice, 3-go Maja 13, 41 800 Zabrze, Poland; E-Mail: (A.P.) |
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| Abstract: | Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces apoptosis in cancer cells and is not toxic to normal cells. We examined the cytotoxic and apoptotic effect of five chalcones in combination with TRAIL on prostate cancer cells. The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was determined using flow cytometry with annexin V-FITC. Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer. |
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| Keywords: | chalcones TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) apoptosis chemoprevention prostate cancer |
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