Biocompatibility of surface treated pure titanium and titanium alloy by<Emphasis Type="Italic">in vivo</Emphasis> and<Emphasis Type="Italic">in vitro</Emphasis> test |
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Authors: | Email author" target="_blank">Min?-Ho?LeeEmail author Dong?-Joo?Yoon Dae?-Hee?Won Tae?-Sung?Bae Fumio?Watari |
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Affiliation: | (1) Department of Materials Science and Engineering, Faculty of Engineering, Kyushu University, Fukuoka 819-0395, Japan;(2) Department of Materials Science and Engineering, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan |
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Abstract: | In the present study, commercial pure Ti and Ti-6Al-4V alloy specimens with and without alkali and heat treatments were implanted
in the abdominal connective tissue of mice. Conventional stainless steel 316L was also implanted for comparison. After three
months, their biocompatibility was evaluated byin vitro andin vivo experiments. Surface structural changes of specimens due to the alkali treatment and soaking in Hank’s solution were analyzed
by XRD, SEM, XPS and AES. An apatite layer, which accelerates the connection with bone, was formed more easily on the alkali
treated specimens than the non-treated specimens. The number of macrophages, which is known to increase as the inflammatory
reaction proceeds, was much lower for the alkali and heat treated specimens than for the others. The average thickness of
the fibrous capsule formed around the implant was much thinner for the alkali and heat treated specimens than for the others. |
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Keywords: | apatite biocompatibility mouse abdominal connective tissue fibrous capsule thickness macrophages |
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