Facile Preparation of Multifunctional WS2/WOx Nanodots for Chelator‐Free 89Zr‐Labeling and In Vivo PET Imaging |
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| Authors: | Liang Cheng Anyanee Kamkaew Sida Shen Hector F Valdovinos Haiyan Sun Reinier Hernandez Shreya Goel Teng Liu Cyrus R Thompson Todd E Barnhart Zhuang Liu Weibo Cai |
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| Affiliation: | 1. Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, China;2. Department of Radiology, University of Wisconsin‐Madison, WI, USA;3. Department of Medical Physics, University of Wisconsin‐Madison, WI, USA;4. Materials Science Program, University of Wisconsin‐Madison, WI, USA;5. University of Wisconsin Carbone Cancer Center, Madison, WI, USA |
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| Abstract: | While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator‐free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom‐up synthesized WS2 nanoflakes, this study fabricates a unique type of WS2/WOx nanodots, which can function as inherent hard oxygen donor for stable radiolabeling with Zirconium‐89 isotope (89Zr). Upon simply mixing, 89Zr can be anchored on the surface of polyethylene glycol (PEG) modified WS2/WOx (WS2/WOx‐PEG) nanodots via a chelator‐free method with surprisingly high labeling yield and great stability. A higher degree of oxidation in the WS2/WOx‐PEG sample (WS2/WOx (0.4)) produces more electron pairs, which would be beneficial for chelator‐free labeling of 89Zr with higher yields, suggesting the importance of surface chemistry and particle composition to the efficiency of chelator‐free radiolabeling. Such 89Zr‐WS2/WOx (0.4)‐PEG nanodots are found to be an excellent PET contrast agent for in vivo imaging of tumors upon intravenous administration, or mapping of draining lymph nodes after local injection. |
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| Keywords: | in vivo PET imaging lymph node imaging stability WS2/WOx nanodots 89Zr‐chelator‐free |
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