| 3-甲基吲哚的合成及其提纯方法 |
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| 引用本文： | 许建帼,史鸿鑫,徐丽丽.3-甲基吲哚的合成及其提纯方法[J].化工生产与技术,2005,12(4):12-14. |
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| 作者姓名： | 许建帼 史鸿鑫 徐丽丽 |
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| 作者单位： | 1. 浙江工业大学浙西分校化工系,浙江,衢州,324006
2. 浙江工业大学化材学院,浙江,杭州,310014 |
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| 摘 要： | 以丙醛、苯肼为原料加热脱水得丙醛苯腙,在氯化锌催化作用下脱氨得3-甲基吲哚。采用分子蒸馏技术来提纯3-甲基吲哚,克服了挥发度小、热敏性强,用普通蒸馏、重结晶分离效果差的缺陷。结果显示,产品外观色泽好、纯度达99.0%以上,蒸馏总收率为32.3%
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| 关 键 词： | 3-甲基吲哚 合成 分子蒸馏 分离 |
| 收稿时间： | 2005-04-05 |
| 修稿时间： | 2005年4月5日 |
Synthesis of 3- Methylindole and Its New Purification Method |
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| Xu Jianguo,Shi Hongxin,Xu Lili.Synthesis of 3- Methylindole and Its New Purification Method[J].Chemical Production and Technology,2005,12(4):12-14. |
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| Authors: | Xu Jianguo Shi Hongxin Xu Lili |
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| Affiliation: | Xu Jianguo1,Xu Lili1,Shi Hongxin2 |
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| Abstract: | Propionaldehyde phenylhydrazone was synthesized from propionaldehyd e and phenyhydrazine through with thermal dehydration, which was de- amined over zinc chloride to get 3- methylindole . Molecular distillation, which was used to purify 3- methylindole, overcame ma ny disadvantages, such as low volatilization, strong thermal sensitivity, and ba d results by normal distillation and crystallization. New methods showed that th e product had a good color, purity had reached over 99.0% . Total distillation yield reached 32.3% . |
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