Cerebrovascular effects of analgosedation |
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| Authors: | C Werner JP Jantzen CK Spiss |
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| Affiliation: | Centre national de référence de la chimiosensibilité du paludisme, H?pital Bichat-Claude Bernard, Paris. |
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| Abstract: | The in vitro drug sensitivity of three dihydrofolate reductase inhibitors (pyrimethamine, cycloguanil, trimethoprim) was determined against 29 strains and isolates of Plasmodium falciparum by an isotopic semi-microtest. Trimethoprim is less active than pyrimethamine or cycloguanil and its activity is correlated with that of two other inhibitors, suggesting cross-resistance in vitro among the dihydrofolate reductase inhibitors. |
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