Novel biodegradable amphiphilic poly(ε‐caprolactone)/poly(N‐vinylpyrrolidone) blends via successive in situ polymerizations |
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| Authors: | Zhimin Xing Tingxiu Xie Guisheng Yang |
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| Affiliation: | 1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastic, Joint Laboratory of Polymer Science and Technology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China;2. Graduate School of the Chinese Academy of Sciences, Beijing 100080, China;3. Shanghai Genius Advanced Materials Co., Ltd, Shanghai 201109, China |
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| Abstract: | In this study, biodegradable blends of poly(ε‐caprolactone) (PCL) and poly(N‐vinylpyrrolidone) (PVP) were prepared by a new strategy in the following steps: (1) free radical polymerization of N‐vinyl‐2‐pyrrolidone (NVP) in ε‐caprolactone (CL); (2) ring‐opening polymerization of ε‐caprolactone in the presence of PVP to obtain the target blends. The structure of the blends was confirmed by FTIR and 1H NMR, and the molecular weight of PCL and PVP were determined by GPC. SEM study revealed that this polymerization method could decrease the disperse phase size and improve the interphase when compared with solution‐blending method. The phase inversion occurred when PVP content was 15–20 wt %. Subsequently, the PCL sphere dispersed in PVP matrix and its size decreased with the increase of PVP content. The contact angle results showed that PVP has a profound effect on hydrophilic properties of PCL/PVP blends. PCL/PVP blends are believed to be promising for drug delivery, cell therapy, and other biomedical applications. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009 |
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| Keywords: | amphiphilic poly(ε ‐caprolactone) poly(N‐vinylpyrrolidone) blends ring‐opening polymerization |
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