Nanostructured Biomaterials for Regeneration |
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| Authors: | Guobao Wei Peter X. Ma |
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| Affiliation: | 1. Department of Biomedical Engineering University of Michigan Ann Arbor, MI 48109 (USA);2. Department of Biologic and Materials Sciences, University of Michigan Ann Arbor, MI 48109 (USA);3. Macromolecular Science and Engineering Center, University of Michigan Ann Arbor, MI 48109 (USA) |
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| Abstract: | Biomaterials play a pivotal role in regenerative medicine, which aims to regenerate and replace lost/dysfunctional tissues or organs. Biomaterials (scaffolds) serve as temporary 3D substrates to guide neo tissue formation and organization. It is often beneficial for a scaffolding material to mimic the characteristics of extracellular matrix (ECM) at the nanometer scale and to induce certain natural developmental or/and wound healing processes for tissue regeneration applications. This article reviews the fabrication and modification technologies for nanofibrous, nanocomposite, and nanostructured drug‐delivering scaffolds. ECM‐mimicking nanostructured biomaterials have been shown to actively regulate cellular responses including attachment, proliferation, differentiation, and matrix deposition. Nanoscaled drug delivery systems can be successfully incorporated into a porous 3D scaffold to enhance the tissue regeneration capacity. In conclusion, nanostructured biomateials are a very exciting and rapidly expanding research area, and are providing new enabling technologies for regenerative medicine. |
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| Keywords: | biomaterials drug delivery nanofibers regenerative medicine tissue engineering |
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