| 辐射交联PVA/PVP/胶原复合水凝胶的制备及性能研究 |
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| 引用本文： | 倪茂君,包文婷,陈竹平.辐射交联PVA/PVP/胶原复合水凝胶的制备及性能研究[J].精细化工,2016,33(3). |
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| 作者姓名： | 倪茂君 包文婷 陈竹平 |
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| 作者单位： | 四川省原子能研究院,四川省原子能研究院,四川省原子能研究院 |
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| 摘 要： | 采用辐射交联与冻融循环相结合的方法,将胶原引入聚乙烯醇(PVA)/聚乙烯基吡咯烷酮(PVP)水凝胶体系,制备具有较高生物活性的PVA/PVP/胶原复合水凝胶。通过含水率、溶胀性能、力学性能及微观结构研究胶原对复合水凝胶结构与性能的影响,并优选最佳体系进行体外细胞毒性实验(MTT法)。研究结果表明,复合水凝胶具有均匀分布的三维多孔结构,胶原的添加增大水凝胶网络空间结构,其初始含水率达92%,并在10 h内达到溶胀平衡,但力学性能降低。辐射交联与冻融循环相结合的方法有利于提高胶原水凝胶制备效率,胶原结构不改变,其体外细胞存活率从PVA/PVP水凝胶的77.3%提高到93.8%,细胞相容性提高。
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| 关 键 词： | 辐射交联 冻融循环 胶原 水凝胶 功能材料 |
| 收稿时间： | 2015/11/2 0:00:00 |
| 修稿时间： | 2016/1/20 0:00:00 |
Preparation and Characterization of PVA/PVP/collagen Composite Hydrogel by Irradiation Crosslinking |
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| NI Mao-jun,Bao Wen Ting and Chen Zhu Ping.Preparation and Characterization of PVA/PVP/collagen Composite Hydrogel by Irradiation Crosslinking[J].Fine Chemicals,2016,33(3). |
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| Authors: | NI Mao-jun Bao Wen Ting and Chen Zhu Ping |
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| Affiliation: | Sichuan Institute of Atomic Energy,Sichuan Institute of Atomic Energy,Sichuan Institute of Atomic Energy |
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| Abstract: | PVA/PVP/ collagen composite hydrogel with high biological activity was prepared by a combination of irradiation crosslinking and freezing/ thawing cycles. The effect of PVP content and collagen on water content, swelling property and mechanical property of the hydrogel were studied. The biocompatibility of PVA/PVP and PVA/PVP/collagen hydrogel was tested by MTT. The results showed that PVA/PVP/collagen hydrogel scaffolds with high swelling property can be obtained by the combination of radiation crosslinking and freezing/ thawing cycles. Collagen was helpful to improve the swelling performance of PVA/PVP hydrogel while the mechanical property was decreased. Biocompatibility study showed that PVA/PVP/collagen hydrogel had better biocompatibility compared with the PVA/PVP hydrogel, and was more conducive to promote cell growth. |
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