Microemulsion of erythromycine for transdermal drug delivery |
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| Authors: | Da Yeon Kim So Mi Yoon Jin Seon Kwon Won Seok Kang Bong Lee Jae Ho Kim Byoung Hyun Min Moon Suk Kim |
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| Affiliation: | 1. Department of Molecular Science and Technology, Ajou University, Suwon 443‐759, Korea;2. Department of Polymer Engineering, Pukyong National University, Busan, 608‐739, Korea |
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| Abstract: | The aim of this work was to prepare an erythromycin (EM) microemulsion (EM‐ microemulsion) for transdermal EM delivery using isotropic mixtures of oil and aqueous phases. The prepared EM‐microemulsion is a white dispersion, with a suitable viscosity for transdermal delivery. In stability experiments, the EM‐microemulsion showed no marked change in appearance for up to 3 weeks at 25°C. In accelerated stability experiments at 37 and 60°C, however, precipitated crystalline EM particles were observed in the EM‐microemulsion. Diffusion of EM into the skin exhibited a first order release profile. Fluorescein (FL)‐microemulsion penetrated to the dermis layer of skin. In conclusion, we confirmed that EM‐microemulsion could serve as an excellent transdermal carrier of EM. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 |
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| Keywords: | drug delivery systems biomedical applications biomaterials |
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