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Synthesis and evaluation of 99m Tc-NIDA and 99m Tc-DMIDA complexes for hepatobiliary imaging |
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| Authors: | M. A. Motaleb H. El-Said M. Abdallah M. Atef |
| Affiliation: | 1. Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt 2. Radioactive Isotopes and Generator Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt 3. Faculty of Science, Zagazig University, Cairo, Egypt |
| Abstract: | 1-Naphthylcarbamoylmethyliminodiacetic acid (NIDA) and diphenylmethylcarbamoylmethyliminodiacetic acid (DMIDA) were synthesized, characterized, and labeled with 99m Tc using SnCl2 as reducing agent. The parameters affecting the yield of 99m Tc-NIDA and 99m Tc-DMIDA were studied in detail. The optimum conditions ensuring high yield of 99m Tc-NIDA (94.2 ± 2%) and 99m Tc-DMIDA (93.1 ± 2%) are as follows: 30 mg of NIDA or DMIDA, 0.3 mg of SnCl2·H2O, pH 6, 15 min. The biodistribution in mice injected with 99m Tc-NIDA and 99m Tc-DMIDA showed high liver uptake at 10 min post injection, with fast biliary excretion. Accumulation of the activity in kidneys was negligible, especially after a long time post injection. Both 99m Tc-NIDA and 99m Tc-DMIDA can be applied as hepatobiliary imaging agents for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct. |
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