| SeO2对维生素D衍生物烯丙位氧化的概述 |
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| 引用本文： | 魏鹏飞,唐甜,李琳,杨丰科. SeO2对维生素D衍生物烯丙位氧化的概述[J]. 当代化工, 2018, 0(1): 116-119. DOI: 10.3969/j.issn.1671-0460.2018.01.032 |
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| 作者姓名： | 魏鹏飞 唐甜 李琳 杨丰科 |
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| 作者单位： | 青岛科技大学化工学院,山东 青岛,266000 |
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| 摘 要： | 维生素D 及其衍生物不仅可以作为治疗疾病的药物,而且也可以成为化学合成的原料.大多数维生素D 衍生物的合成都需要经过烯丙位的氧化,然而维生素D 衍生物烯丙位氧化产率很低,这对维生素D 衍生物的开发和研究带来了困难.因此对近年来以二氧化硒为氧化剂对维生素D 衍生物进行烯丙位氧化—环氧法和Riley 氧化法进行了总结,并对此近年来研究成果进行了分析总结.
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| 关 键 词： | 维生素D衍生物 烯丙位 氧化 二氧化硒 维生素D Vitamin d derivatives Allylic position Oxidation Selenium dioxide Vitamin D |
Overview on Allylic Oxidation of Vitamin D Derivatives by SeO2 |
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| WEI Peng-fei,TANG Tian,LI Lin,YANG Feng-ke. Overview on Allylic Oxidation of Vitamin D Derivatives by SeO2[J]. Contemporary Chemical Industry, 2018, 0(1): 116-119. DOI: 10.3969/j.issn.1671-0460.2018.01.032 |
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| Authors: | WEI Peng-fei TANG Tian LI Lin YANG Feng-ke |
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| Abstract: | Vitamin D and its derivatives can not only be used as a drug for the treatment of diseases, but also can be used as raw materials for chemical synthesis. The synthesis of most vitamin D derivatives requires the oxidation of allylic position, but the yield of vitamin D derivative allylic oxidation is very low, which will bring difficulties in developing and researching the vitamin D derivatives. In this paper, epoxy method and Riley oxidation method for allylic oxidation of vitamin D derivatives by using selenium dioxide as oxidant were introduced, and the results of this research in recent years were analyzed and summarized. |
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