Biosynthetic approach for the production of new aminoglycoside derivative |
| |
| Authors: | Keshav Kumar Nepal Jin Cheol Yoo Jae Kyung Sohng |
| |
| Affiliation: | 1 Department of Pharmaceutical Engineering, SunMoon University, # 100, Kalsan-ri, Tangjeong-myeon, Asan-si, Chungnam 336-708, Republic of Korea;2 Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 501-759, Korea |
| |
| Abstract: | Aminoglycoside antibiotics can be classified into two major groups; streptamine containing and 2-deoxystreptamine containing antibiotics. Here, we report a biosynthetic approach for the fusion of spectinomycin and kanamycin biosynthetic gene clusters to yield the new aminoglycoside derivative, oxykanamycinC, in a non-aminoglycoside producing heterologous host. |
| |
| Keywords: | Aminoglycoside Heterologous host Kanamycin Oxykanamycin Streptomyces kanamyceticus |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
