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Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making.
Authors:Schweimer, Judith   Saft, Simone   Hauber, Wolfgang
Abstract:
This study examined whether catecholamine-mediated signals in the anterior cingulate cortex (ACC) contribute to effort-based decision making. Rats were tested after 6-hydroxydopamine or vehicle infusions into the ACC in a T maze cost-benefit task in which the rats could choose either to climb a barrier to obtain a high reward in one arm or run into the other arm without a barrier to obtain a low reward. Results demonstrate that infusions of 6-hydroxydopamine induced a near total loss of tyrosine hydroxylase-positive fibers in the ACC. Unlike sham-lesioned rats, 6-hydroxydopamine-lesioned rats exhibited a reduced preference for the high-cost-high-reward response option when given the choice of obtaining a low reward with little effort. Thus, catecholamine-mediated signals in the ACC could play a role in effort-based decision making. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
Keywords:catecholamine   rats   anterior cingulate cortex   cost benefit   dopamine   reward magnitude   decision making   effort
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