Cholesterol transport and uptake in miniature swine fed vegetable and animal fats and proteis. 1. Plasma lipoproteins and LDL clearance |
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Authors: | Lynnette S Walsh Hentges Donald C Beitz Norman L Jacobson A Dare McGilliard Jeffrey J Veenhuizen |
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Affiliation: | (1) Nutritional Physiology Group, Department of Animal Science, Iowa State University, 50011 Ames, IA;(2) Present address: Dept. of Foods and Nutrition, The University of Georgia, 30602, GA, Athens;(3) Iowa State University, 313 Kildee Hall, 50011 Ames, IA |
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Abstract: | In a 2×2 factorial arrangement, miniature pigs were fed four diets containing vegetable protein/fat (soybean) and animal protein
(egg white)/fat (beef tallow) to demonstrate the effects of protein and fat source on total plasma cholesterol, lipoprotein
distribution, low density lipoprotein (LDL) composition, and plasma clearance of LDL-cholesterol and protein. Beef tallow
consumption resulted in greater plasma cholesterol concentration, decreased LDL-cholesterol concentration, and a lower LDL-cholesterol
to LDL-protein ratio than did consumption of soybean oil. High density lipoprotein (HDL)-cholesterol concentration was increased
by beef tallow consumption. Cholesterol percentage by weight in LDL was significantly greater in pigs consuming soybean oil
than those consuming beef tallow. Percentages by weight of protein, triglyceride and phospholipid in LDL were not significantly
different in any group. Dietary protein source had no significant effect on total plasma cholesterol concentration, lipoprotein
concentration or LDL composition. Egg white consumption decreased fractional catabolic rate and irreversible loss of LDL-cholesterol
and LDL-protein when compared with consumption of soy protein. Dietary fat source had no consistent effect on LDL clearance
from plasma. Dietary fat and protein seemed to influence lipoprotein metabolism by different mechanisms. Fat source altered
lipoprotein concentration and LDL composition, whereas protein source affected the removal rate of LDL from plasma.
Data taken from a dissertation submitted to Iowa State University by L. S. Walsh Hentges as partial fulfillment of the requirements
for the Ph.D. degree. A preliminary paper, was presented at the meeting of the American Oil Chemists' Society in Dallas, Texas,
May, 1984. |
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