T cells expressing killer cell inhibitory receptors do not carry TCR for alloantigens |
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| Authors: | N Yamada T Nagatani M Takiguchi |
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| Affiliation: | Department of Tumor Biology, Institute of Medical Science, University of Tokyo, Japan. |
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| Abstract: | The role of T cells carrying the killer cell inhibitory receptor (KIR) is unknown. Here we investigate the allo-response of KIR+ CD3+ cells (KIR+ T cells). KIR+ T cells was found in 4.6-14.7% of the T cells from the PBMC of healthy individuals. Flow cytometry analysis showed that the percentage of KIR+ T cells in T cells from three individuals was decreased after stimulation with allogeneic PBMC. These findings suggest that KIR+ T cells do not respond to alloantigens. Furthermore, the analyses using purified KIR+ T cells also confirmed that KIR+ T cells do not respond to alloantigens. |
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