Synthetic chiral chromophoric bilayer membranes as chemical transducers: effect of alcohols on enhanced circular dichroism |
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| Authors: | Koji Nakano Isamu Moriguchi Naotoshi Nakashima Makoto Takagi |
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| Affiliation: | (1) Department of Organic Synthesis, Faculty of Engineering, Kyushu University, 812 Fukuoka, Japan;(2) Present address: Department of Industrial Chemistry, Faculty of Engineering, Nagasaki University, 852 Nagasaki, Japan |
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| Abstract: | A bilayer-forming synthetic lipid containing a chiral centre and a chromophoric group was investigated as a spectroscopic transducer, based on its enhanced circular dichroism (CD). The CD intensity of chiral bilayers was reduced with addition of alcohol. For ten additives tested, a linear correlation was observed between the CD spectral response to the alcohols and their partition coefficient (logP) in octanol/water system. By use of an immobilization technique, the bilayer film was obtained on a quartz plate, and a possible application as a solid-phase assay of methanol was demonstrated. |
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