The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy |
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| Authors: | Chunli Wang Lingzu Kong Seokmin Kim Sunyoung Lee Sechan Oh Seona Jo Inhwan Jang Tae-Don Kim |
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| Affiliation: | 1.Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea;2.Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea;3.Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea;4.Department of Life Sciences, Korea University, Seoul 02841, Korea |
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| Abstract: | ![]()
Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R). IL-7 is closely associated with tumor development and has been used in cancer clinical research and therapy. In this review, we first summarize the roles of IL-7 and IL-7Rα and their downstream signaling pathways in immunity and cancer. Furthermore, we summarize and discuss the recent advances in the use of IL-7 and IL-7Rα as cancer immunotherapy tools and highlight their potential for therapeutic applications. This review will help in the development of cancer immunotherapy regimens based on IL-7 and IL-7Rα, and will also advance their exploitation as more effective and safe immunotherapy tools. |
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| Keywords: | IL-7 IL-7R signal cancer immunotherapy |
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