脂肪酶和醇腈酶在有机合成中的应用

有机相酶催化反应常用于高附加值产品的合成。脂肪酶是有机合成中一种重要的工具酶，可以催化酯交换反应。脂肪酶催化的酯的氨解反应已经用于手性酰胺的合成，烷氧羰基化也广泛应用于一些天然化合物的化学选择性修饰。以前在有机合成中很少实用的裂合酶如(R)-醇腈酶在合成具有旋光性的氰醇中的应用也开始引起人们的关注。

Applications of Lipases and (R)-oxynitrilases in Organic Synthesis

Enzyme catalysis reaction in organi c phase is used in the synthesis of hig hly valued products.Lipase is an imp ortant tool to catalyze ester exchange reactions.Ester ammonolysis reactions by lipase catalysis have been used in the pre paration of chirl amides.Enzymatic carbalkoxylatio n has also been used in selectively ch emical reactions of natural compoun ds.Meanwhile,applications of lyase such as(r)-oxynitrilases,which are seldom used in organic synthesis,in synthesis of optically active cyanohydrins h ave attracted people' s attentions.