枸杞籽油和亚麻籽油混合物对小鼠增强免疫功能的影响

目的研究枸杞籽油和亚麻籽油混合物对小鼠免疫力的增强作用。方法选用200只健康ICR小鼠随机分为5大组,每大组40只小鼠按体质量随机分为4小组,即枸杞籽油和亚麻籽油混合物低、中、高剂量组(0.25、0.50、1.50 g/kg BW)和对照组。连续经口灌胃30天后,检测枸杞籽油和亚麻籽油混合物对小鼠免疫器官脏体比、细胞免疫、体液免疫、单核-巨噬细胞吞噬功能和NK细胞活性等指标的影响。结果与对照组比较,中、高剂量组能明显提高小鼠迟发型变态反应能力及NK细胞活性,差异有统计学意义(P0.05),高剂量组能明显提高血清半数溶血值、抗体生成细胞数,差异有统计学意义(P0.05)。各剂量组对小鼠胸腺/体质量比值、脾脏/体质量比值、单核-巨噬细胞碳廓清能力、淋巴细胞转化能力及巨噬细胞吞噬鸡红细胞能力均无明显影响,差异无统计学意义(P0.05)。结论枸杞籽油和亚麻籽油混合物具有增强小鼠免疫力的功能。

Effects of mixture of lycium seed oil and flaxseed oil on immune function in mice

To study the effect of boxthorn seed oil and flaxseed oil complex on mice immunity.Methods Chose 200 institute of cancer research(ICR)mice and divided into five groups, and 40 mice in each group were randomly divided into 4 subgroups according to body weight, including three different doses(0.25,0.50,1.50 g/kg BW)and the control. After gavage administration of 30 days, body weight, immune organ-body ratios, cell immunity, humoral immunity, mononuclear macrophage phagocytosis and natural killer(NK)cell activity index were measured. Results Compared with the control group, the medium and high dose groups had significantly increased delayed-type hypersensitivity(DTH)and NK cell activity(P<0.05). The high dose groups also showed a significant increase in half hemolytic content(HC₅₀)and antibody generating cell(P<0.05). There were no significant changes in body weight gains, immune organ-body ratios, mononuclear macrophage phagocytosis and lymphocyte transformation capability(P>0.05).Conclusion Boxthorn seed oil and flaxseed oil had positive effects on mice immune function.