| R-(+)硫-代四氢呋喃-2-甲酸的合成 |
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| 引用本文： | 孙可一,王平,杨永忠,吴鑫琦,房发俐.R-(+)硫-代四氢呋喃-2-甲酸的合成[J].应用化工,2009,38(12):1824-1825. |
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| 作者姓名： | 孙可一 王平 杨永忠 吴鑫琦 房发俐 |
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| 作者单位： | 西安瑞联近代电子材料有限责任公司,陕西,西安,710077 |
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| 摘 要： | 以R-(+四)-氢呋喃-2-甲酸为原料,通过草酰氯酰化,与NaHS发生取代反应,合成R-(+)硫-代四氢呋喃-2甲-酸,粗品经柱层析,减压蒸馏纯化。产品收率53.3%,产物结构经MS,1H NMR确认。
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| 关 键 词： | R-(+硫)-代四氢呋喃-2-甲酸 R-(+)四-氢呋喃-2甲-酸 法罗培南 |
The synthesis of R-(+)-thiotetrahydrofuran-2-carboxylic acid |
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| SUN Ke-yi,WANG Ping,YANG Yong-zhong,WU Xin-qi,FANG Fa-li.The synthesis of R-(+)-thiotetrahydrofuran-2-carboxylic acid[J].Applied chemical industry,2009,38(12):1824-1825. |
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| Authors: | SUN Ke-yi WANG Ping YANG Yong-zhong WU Xin-qi FANG Fa-li |
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| Abstract: | R-(+)-thiotetrahydrofuran-2-carboxylic acid was synthesized via R-(+)-tetrahydrofuran-2-carboxylic acid by acylation using oxalyl chloride followed by step of substitution reaction using sodium hydrosulfide.The crude product was purified by chromatography column and vacuum distillation.The overall yield was 53.3% and the products was confirmed by MS and ~1H NMR. |
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| Keywords: | R-(+)-thiotetrahydrofuran-2-carboxylic acid R-(+)-tetrahydrofuran-2-carboxylic acid faropenem |
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