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甲鱼抗氧化肽对非酶糖基化反应及其终产物的抑制作用
引用本文:王楠,章涵钰,楼博,王伟,史学波.甲鱼抗氧化肽对非酶糖基化反应及其终产物的抑制作用[J].中国食品学报,2022,22(2):58-64.
作者姓名:王楠  章涵钰  楼博  王伟  史学波
作者单位:浙江树人学院生物与环境工程学院 杭州 310015;浙江省农业科学院农产品质量标准化研究所 杭州 310021;浙江中得农业集团有限公司 杭州 310021
基金项目:浙江省自然科学基金项目(LY17C200012)
摘    要:建立体外非酶糖基化蛋白质-还原糖模拟反应体系的基础上,探究甲鱼抗氧化肽对非酶糖基化反应的抑制率(NEG)和晚期糖基化终末产物(AGEs)抑制率的影响.结果表明:甲鱼抗氧化肽能够抑制非酶糖基化反应和晚期糖基化终产物的产生,具有剂量依赖性.当甲鱼抗氧化肽处理蛋白质-还原糖体系21 d时,1.00 mg/mL甲鱼抗氧化肽对N...

关 键 词:甲鱼抗氧化肽  非酶糖基化反应  晚期糖基化终末产物  抑制作用
收稿时间:2021/2/11 0:00:00

Inhibitory Effect of Antioxidant Peptides of Turtle on Non-enzymatic Gluco-sylation and Its End Products
Wang Nan,Zhang Hanyu,Lou Bo,Wang Wei,Shi Xuebo.Inhibitory Effect of Antioxidant Peptides of Turtle on Non-enzymatic Gluco-sylation and Its End Products[J].Journal of Chinese Institute of Food Science and Technology,2022,22(2):58-64.
Authors:Wang Nan  Zhang Hanyu  Lou Bo  Wang Wei  Shi Xuebo
Affiliation:(College of Biology and Environmental Engineering,Zhejiang Shuren University,Hangzhou 310015;Institute of Quality and Standard for Agricultural Products,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021;Zhejiang Zhongde Agriculture Group Co.Ltd.,Hangzhou 310021)
Abstract:On the basis of establishing the simulated reaction system of non-enzyme gluco-sylation protein and reducing sugar in vitro,the inhibitory effect of turtle antioxidant peptide on non-enzyme gluco-sylation(NEG)reaction and advanced glycation end products(AGEs)was investigated.The results showed that the mass concentration of anti-oxidation peptide was 1.00 mg/mL,and the inhibition rate of NEG was 68.79%when incubated for 21 days,the inhibition rate of AGEs was 89.35%when incubated for 28 days.Infrared spectroscopy results proved that antioxidant peptide of turtle could effectively inhibit the production of AGEs in non-enzymatic gluco-sylation reaction.
Keywords:turtle antioxidant peptide  non-enzymatic gluco-sylation reaction  advanced glycation end products  inhibitory effect
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