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| Development of X-ray dark-field imaging towards clinical application | |
| 作者姓名： | ANDOMasami HASHIMOTOEiko HASHIZUMEHiroyuki HYODOKazuyuki INOUEHajime ISHIKAWATetsuya KUNISADAToshiyuki MAKSIMENKOAnton PATTANASIRIWISAWAWanwisa RUBENSTEINEdward ROBERSONJoseph SHIMAODaisuke SUGIYAMAHiroshi TAKEDAKen UENOEi WADAHiroshi |
| 作者单位： | [1]PhotonFactory,KEK,Oho1-1,Tsukuba,Ibaraki305-0801,Japan [10]DeptofBiorobotics,SchoolofEngineering,TohokuUniversity,Aobayama01,Sendai980-8579,Japan [2]DepartmentofPhoto-Science,GraduateUniversityforAdvancedStudies,Hayama,Miura,Kanagawa240-0193,Japan [3]DepartmentofOrthopaedicSurgery,OkayamaUniversityGraduateSchoolofMedicineandDentistry2-5-1,Shikata-cho,Okayama700-8558,Japan [4]DepartmentofMaterialStructuralSciences,GraduateUniversityforAdvancedStudies,Oho1-1,Tsukuba,Ibaraki305-0801,Japan [5]RIKENHarima,Koto1-1-1,Mikazuki-cho,Sayo-gun,Hyogo-ken679-5198,Japan [6]SuranareeUniversityofTechnology,MuangDistrict,UniversityAvenue1111,NakhonRachasima30000,Thailand [7]DepartmentofMedicineStanfordUniversitySchoolofMedicine,Stanford,CA94305,USA [8]CaliforniaEarInstitute,Stanford,CA94304,USA [9]DepartmentofBreast-Thyroid-EndorineSurgery,InstituteofClinicalMedicine,TsukubaUniversity,Tsukuba,Ibaraki305-0006,Japan |
| 摘 要： | Review of X-ray dark-field imaging under development is presented. Its goal is its application to clini-cal diagnosis of organs that have been invisible by the ordinary techniques. In order to clinically visualize tissues in detail one needs high contrast and high spatial resolution say～50μm. This X-ray optics comprises a Bragg asymmet-ric monochro-collimator and a Bragg case or a Laue case filter with capability of analyzing angle in a parallel posi-tion. Their diffraction index is 4,4,0 and the X-ray energy 35 keV (λ=0.0354 nm). The filter has 0.6 mm thickness in the Bragg case or 1.075 mm or 2.15 mm thickness in the Laue case. Under this condition only the refracted X-rays from object can transmit through the filter while the beam that may receive absorption and/or phase change will not.Soft tissues at human joints thus taken show high contrast images so that the DFI is promising for clinical diagnosis.Preliminary X-ray absorption images of another clinical candidates of ear bones are also shown. |
| 关 键 词： | X射线暗场成像 X射线亮场成像 X射线诊断学 布拉格滤波器 布拉格不对称单色准直仪 |
Development of X-ray dark-field imaging towards clinical application |
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| ANDOMasami HASHIMOTOEiko HASHIZUMEHiroyuki HYODOKazuyuki INOUEHajime ISHIKAWATetsuya KUNISADAToshiyuki MAKSIMENKOAnton PATTANASIRIWISAWAWanwisa RUBENSTEINEdward ROBERSONJoseph SHIMAODaisuke SUGIYAMAHiroshi TAKEDAKen UENOEi WADAHiroshi.Development of X-ray dark-field imaging towards clinical application[J].Nuclear Science and Techniques,2004,15(3):129-139. | |
| Authors: | ANDO Masami HASHIMOTO Eiko HASHIZUME Hiroyuki HYODO Kazuyuki INOUE Hajime ISHIKAWA Tetsuya KUNISADA Toshiyuki MAKSIMENKO Anton PATTANASIRIWISAWA Wanwisa RUBENSTEIN Edward ROBERSON Joseph SHIMAO Daisuke SUGIYAMA Hiroshi TAKEDA Ken UENO Ei WADA Hiroshi |
| Affiliation: | 1. Photon Factory, KEK, Oho 1-1, Tsukuba, Ibaraki 305-0801, Japan;Department of Photo-Science, Graduate University for Advanced Studies, Hayama, Miura, Kanagawa 240-0193, Japan;Department of Material Structural Sciences, Graduate University for Advanced Studies,Oho 1-1,Tsukuba,ibaraki 305-0801,Japan 2. Department of Photo-Science, Graduate University for Advanced Studies, Hayama, Miura, Kanagawa 240-0193, Japan 3. Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine and Dentistry 2-5-1, Shikata-cho, Okayama 700-8558, Japan 4. Photon Factory, KEK, Oho 1-1, Tsukuba, Ibaraki 305-0801, Japan;Department of Material Structural Sciences, Graduate University for Advanced Studies, Oho 1-1, Tsukuba, Ibaraki 305-0801, Japan 5. RIKEN Harima, Koto 1-1-1,Mikazuki-cho, Sayo-gun, Hyogo-ken 679-5198, Japan 6. Suranaree University of Technology, Muang District, University Avenue 1111, Nakhon Rachasima 30000, Thailand 7. Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA 8. California Ear Institute, Stanford, CA 94304 USA 9. Department of Material Structural Sciences, Graduate University for Advanced Studies,Oho 1-1,Tsukuba,ibaraki 305-0801,Japan 10. Photon Factory, KEK, Oho 1-1, Tsukuba, Ibaraki 305-0801, Japan;Department of Photo-Science, Graduate University for Advanced Studies, Hayama, Miura, Kanagawa 240-0193, Japan 11. Departraent of Breast-Thyroid-Endorine Surgery, Institute of Clinical Medicine, Tsukuba University, Tsukuba, Ibaraki 305-0006, Japan 12. Dept of Biorobotics, School of Engineering, Tohoku University, Aobayama 01, Sendai 980-8579, Japan |
| Abstract: | Review of X-ray dark-field imaging under development is presented. Its goal is its application to clinical diagnosis of organs that have been invisible by the ordinary techniques. In order to clinically visualize tissues in detail one needs high contrast and high spatial resolution say ～50 μm. This X-ray optics comprises a Bragg asymmetric monochro-collimator and a Bragg case or a Laue case filter with capability of analyzing angle in a parallel position. Their diffraction index is 4,4,0 and the X-ray energy 35 keV (λ= 0.0354 nm). The filter has 0.6 mm thickness in the Bragg case or 1.075 mm or 2.15 mm thickness in the Laue case. Under this condition only the refracted X-rays from object can transmit through the filter while the beam that may receive absorption and/or phase change will not. Soft tissues at human joints thus taken show high contrast images so that the DFI is promising for clinical diagnosis. Preliminary X-ray absorption images of another clinical candidates of ear bones are also shown. |
| Keywords: | X-ray dark-field imaging X-ray bright-field imaging Bragg asymmetric monochro-collimator Bragg case filter Laue case filter Clinical diagnosis |
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