Miconazole Chewing Gum as a Drug Delivery System Application of Solid Dispersion Technique and Lecithin |
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Authors: | Morten Pedersen Margrethe R Rassing |
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Affiliation: |
a Department of Pharmaceutics, Royal Danish School of Pharmacy 2 Universitetsparken, Copenhagen, Denmark |
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Abstract: | The release of the antifungal drug miconazole from chewing gum was evaluated both in vitro and in vivo. It was proved that the addition of lecithin and the application of a miconazole polyethyleneglycol 6000 solid dispersion increased the release of miconazole from chewing gum. The in vitro results correlated well with the in vivo results. 6 healthy volunteers obtained therapeutically active concentrations of miconazole in saliva when they chewed gum. In the microbiological experiments performed, lecithin did not antagonize the anti-Candida albicans effect of miconazole at pH 7.2. |
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