Solubility of Sodium Phenytoin in Ethanol + Water Mixtures at Various Temperatures

The solubility of sodium phenytoin in binary mixtures of ethanol + water at 298.2, 303.2, 308.2, and 313.2 K was measured. The solubility was increased by addition of ethanol, reached a maximum value at 0.50 mass fraction of ethanol, and then decreased with further increase of ethanol. At all temperatures, the solubility of the solute in neat water was greater than that of neat ethanol. The Jouyban–Acree model and its combined version with the van't Hoff equation were used to predict the reported solubilities, resulting in a mean relative deviation of 12.7 and 13.7%, respectively.