| 丹皮酚磺酸钠的合成及精制 |
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| 引用本文： | 段义杰,张朋,薛胜将,刘存领. 丹皮酚磺酸钠的合成及精制[J]. 中国化工贸易, 2013, 0(7): 327-327,444 |
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| 作者姓名： | 段义杰 张朋 薛胜将 刘存领 |
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| 作者单位： | 山东方明药业集团股份有限公司,山东东明274500 |
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| 摘 要： | 目的：提高丹皮酚磺酸钠制备的收率，并提供一种新的精制方法。方法：以氯磺酸做磺化试剂，乙酸乙酯做溶剂，60~C／~应1h，与氯化钠成盐后，经活性炭脱色，乙醇精制，得到高纯度的丹皮酚磺酸钠。结果：合成了有关物质、氯离子、硫酸根离子均合格的丹皮酚磺酸钠，三步综合收率不低于60％。结论：该工艺路线成本较低，操作简单，收率高，适合工业化生产。
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| 关 键 词： | 丹皮酚磺酸钠 合成 精制 |
Studies on the synthesis and purification of sodium paeonol |
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| DUAN Yi-jie,ZHANG PENG XUE Sheng-jiang,LIU Cun-ling. Studies on the synthesis and purification of sodium paeonol[J]. CHINA CHEMICAL TRADE, 2013, 0(7): 327-327,444 |
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| Authors: | DUAN Yi-jie ZHANG PENG XUE Sheng-jiang LIU Cun-ling |
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| Affiliation: | (Shandong Fangming Pharmaceutical Group Co.,Ltd., Dongming 274500, China) |
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| Abstract: | Objective： To provide a new method of synthesis and purification of sodium paeonol in order to improve the yield. Method： Take chlorosulfonic acid as sulfonating agent, ethyl acetate as solvent, reaction at 60 ℃for lb. After reacted with sodium chloride, decoloried by active carbon, purification in ethanol to get high purity sodium paeonol. Results： Sodium paeonol was synthesized in overall yield at least 60%, related substances, chloride ions, sulfate ions were qualified. Conclusion： The improved process has advantages of lower cost, high yield, conve- nient work- up. It is suitable for industrial oroduction. |
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| Keywords: | sodium paeonol synthesis purification |
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