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Design of the spherical agglomerate size in crystallization by developing a two-step bridging mechanism and the model |
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| Authors: | Changyou Yu Menghui Yao Yiming Ma Yanbo Liu Shilin Guo Shijie Xu Sohrab Rohani Mingyang Chen Junbo Gong |
| Affiliation: | 1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072 China;2. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072 China Contribution: Conceptualization (lead), Data curation (lead), Formal analysis (lead), Investigation (lead), Methodology (lead), Validation (lead), Writing - review & editing (lead);3. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072 China Contribution: Investigation (supporting), Validation (equal), Writing - review & editing (equal);4. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072 China Contribution: Investigation (equal), Validation (supporting);5. Tianjin Key Laboratory of Marine Resources and Chemistry, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, China;6. Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario, Canada |
| Abstract: | Spherical agglomeration technology can produce high-performance spherical particles in a single crystallization unit, although it is still challenging to control the particle size and shape. To solve this issue, a two-step bridging (TSB) mechanism containing a preconditioning period, size period, and shape period is proposed. The dynamic balance among the forces of adhesion, dispersion, and capillary action in the multi-liquid phases plays a key role. This is fully considered to establish the TSB-based thermodynamic size model and particle design framework by weighting the force action regions in multi-liquid phases with dynamic composition. The spherical agglomerates of benzoic acid, celecoxib, and salicylic acid with narrow particle size distributions and tunable particle size ranges of 2000–5000, 800–3500, and 1500–4500 μm, respectively, were designed and prepared successfully, showing good correlation with the calculation, which is superior to the reported methods and indicates that the mechanism has certain universality and guiding significance. |
| Keywords: | granulation particle engineering spherical agglomeration the Lifshitz-van der Waals acid–base approach two-step bridging (TSB) mechanism |