Cytotoxic Petrosiacetylenes from the Marine Sponge Petrosia sp. |
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| Authors: | Yeon-Ju Lee Su-Jung Yoo Jong Soon Kang Jieun Yun Hee Jae Shin Jong Seok Lee Hyi-Seung Lee |
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| Affiliation: | 1. Korea Institute of Ocean Science and Technology, Ansan, 426-744, Republic of Korea
2. Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, 363-883, Republic of Korea
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| Abstract: | A novel petrosiacetylene analog (petrosiacetylene E) has been isolated from the Korean marine sponge Petrosia sp., along with petrosiacetylene A, B and C. Their structures were elucidated on the basis of spectroscopic methods and the stereochemistry of the new compound was determined by using the modified Mosher’s method. Petrosiacetylene E showed higher cytotoxicity against five human cancer cell lines than petrosiacetylene A and B, presumably due to the additional hydroxy group located at C-16. |
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| Keywords: | Sponge Petrosia Polyacetylenic alcohol Petrosiacetylene Cytotoxicity |
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