| （R）-巴氯芬的合成研究 |
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| 引用本文： | 陈云华,毛侦军,杨伟强,林旭锋. （R）-巴氯芬的合成研究[J]. 浙江化工, 2008, 39(12) |
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| 作者姓名： | 陈云华 毛侦军 杨伟强 林旭锋 |
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| 作者单位： | 1. 浙江海正药业股份有限公司,浙江台州,318000
2. 浙江大学理学院化学系,浙江杭州,310027 |
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| 摘 要： | 从对氯苯乙酮出发,经过Wittig-Horner、溴代、酞酰亚胺化、不对称还原和酸解反应五步合成了(R)-巴氯芬,总收率达到了62%。目标产物的结构经过核磁和质谱的确证。
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| 关 键 词： | (R)-巴氯芬 不对称催化 合成 |
New Technical Synthesis of(R)-Baclofen |
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| CHEN Yun-hua,YANG Wei-qiang,MAO Zhen-jun,LIN Xu-feng. New Technical Synthesis of(R)-Baclofen[J]. Zhejiang Chemical Industry, 2008, 39(12) |
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| Authors: | CHEN Yun-hua YANG Wei-qiang MAO Zhen-jun LIN Xu-feng |
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| Abstract: | The synthetic method on (R)-baclofen is described in detail. Using 4-chloro-acetophenone as materials, (R)-baclofen is synthesized by five steps of Wittig -Horner, bromo reaction, phthalimide, enantioselective conjugate reduction and acidlysis reaction.The product yield is 62%.The structure of the product was determined by 1H NMR and MS. |
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| Keywords: | (R)-baclofen asymmetric catalysis synthesis |
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