利用HFETR制备有载体177Lu

¹⁷⁷Lu是一种优良的诊疗一体化医用放射性核素，其标记的放射性药物被广泛用于多种癌症的诊断和治疗。其中，有载体¹⁷⁷Lu的制备具有放射化学处理简单、¹⁷⁷Lu产量高等优点。为此，在高通量工程试验堆(HFETR)中利用热中子辐照¹⁷⁶Lu,开展有载体¹⁷⁷Lu的制备研究。本研究分别辐照天然Lu和富集¹⁷⁶Lu进行热实验验证，结果表明：天然Lu在2×10¹⁴ n·cm^-2·s^-1热中子通量下辐照13 d,生成¹⁷⁷Lu比活度约为0.87 Ci/mg,^177mLu杂质含量为0.009%;富集(86.5%)¹⁷⁶Lu在热中子注量率为1×10¹⁴ n·cm^-2·s^-1条件下辐照28 d,生成¹⁷⁷Lu比活度约为24.9 Ci/mg,^177m...

Production of Carrier Added 177Lu in HFETR

As an ideal medical theranostic radionuclide, ¹⁷⁷Lu is widely applied in many cancer diagnostics and therapies. The carrier added 177Lu has the advantages of simple radiochemical process and high irradiation yield. Herein, this paper conducted the research on the preparation of carrier added ¹⁷⁷Lu by thermal neutron irradiation of ¹⁷⁶Lu in the high flux engineering test reactor (HFETR). This work irradiated natural lutetium and enriched ¹⁷⁶Lu. As a result, ¹⁷⁷Lu with specific activity of 0.87 Ci/mg and ^177mLu content of 0.009% was produced by 13 days irradiation of natural Lu at thermal neutron flux of 2×10¹⁴ n·cm^-2·s^-1; ¹⁷⁷Lu with specific activity of 24.9 Ci/mg and 177mLu content of 0.02% was produced by 28 days irradiation of enriched ¹⁷⁶Lu (86.5%) at thermal neutron flux of 1×10¹⁴ n·cm^-2·s^-1; ¹⁷⁷Lu with specific activity of 25.76 Ci/mg and ^177mLu content of 0.002% was produced by 5 days irradiation of enriched ¹⁷⁶Lu (86.5%) at thermal neutron flux of 2×1014 n·cm-2·s-1; and ¹⁷⁷Lu with specific activity of 28.3 Ci/mg and 177mLu content of 0.009% was produced by 12 days irradiation of enriched ¹⁷⁶Lu (86.5%) at thermal neutron flux of 2×10¹⁴ n·cm^-2·s^-1. Among them, both ¹⁷⁷Lu products using enriched ¹⁷⁶Lu targets meet the domestic group requirements with specific activity more than 20 Ci/mg and ^177mLu/¹⁷⁷Lu less than 0.07%. Overall, carrier added ¹⁷⁷Lu which can meet the standards can be prepared by irradiation of enriched ¹⁷⁶Lu in HFETR. It is expected to realize localized production of carrier added ¹⁷⁷Lu according to market demand and promote the domestic researches in ¹⁷⁷Lu nuclear medicine applications.