Neuropsychological correlates of single photon emission computed tomography (SPECT) in Alzheimer's disease.

Examined associations between regional cortical perfusion on SPECT scans and cognitive test performance in 15 patients (mean age 67.1 yrs) with probable Alzheimer's disease (AD) of mild to moderate severity. The degree and extent of decreased perfusion of SPECT scans was associated with severity of AD and neuropsychological test scores correlated with findings of lateralized perfusion deficits on SPECT scans. Perfusion deficits on SPECT scans were also associated with estimates of global changes in intellectual functioning. Instruments included the Wechsler Adult Intelligence Scale—Revised (WAIS—R), the Mini-Mental State Examination, the Aphasia Screening Test, and the Trail Making Test. (PsycINFO Database Record (c) 2010 APA, all rights reserved)