| 花生肽对半乳糖致大鼠肝损伤的抑制作用 |
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| 引用本文： | 陈贵堂,赵立艳,赵霖,綦国红,李博,王岁楼.花生肽对半乳糖致大鼠肝损伤的抑制作用[J].食品科学,2011,32(5):296-300. |
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| 作者姓名： | 陈贵堂 赵立艳 赵霖 綦国红 李博 王岁楼 |
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| 作者单位： | 1.中国药科大学药学院 2.南京农业大学食品科技学院 3.中国人民解放军总医院营养科 |
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| 摘 要： | 为研究花生肽对D-半乳糖诱导的大鼠化学性肝损伤的保护作用，将50只SD大鼠随机分为5组(对照组、模型组、低中高剂量花生肽组)，除对照组外，其余各组大鼠按其体质量每天皮下注射D-半乳糖400mg/kg建立氧化损伤模型，同时3个花生肽组每天分别按200、500、800mg/kg的剂量灌胃，持续50d。检测血清生化指标以及肝脏中脂褐素含量和抗氧化酶活力，并进行肝组织病理学镜检。结果表明，花生肽能明显对抗氧化损伤大鼠血清中总胆汁酸的积累，抑制谷丙转氨酶和碱性磷酸酶活力的升高，提高肝脏中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活力，并能够降低大鼠肝脏中的脂褐素含量，有效减轻大鼠肝脏的组织病理形态学变化。表明花生肽对D-半乳糖诱导的大鼠肝损伤有一定的保护作用。
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| 关 键 词： | 花生肽 肝损伤 D-半乳糖 保肝 |
| 收稿时间： | 2010-06-30 |
Hepatoprotective Effect of Peanut Peptide in D-Galactose-induced Liver Damage in Rats |
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| CHEN Gui-tang,ZHAO Li-yan,ZHAO Lin,QI Guo-hong,LI Bo,WANG Sui-lou.Hepatoprotective Effect of Peanut Peptide in D-Galactose-induced Liver Damage in Rats[J].Food Science,2011,32(5):296-300. |
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| Authors: | CHEN Gui-tang ZHAO Li-yan ZHAO Lin QI Guo-hong LI Bo WANG Sui-lou |
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| Affiliation: | 1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China；
2. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China；
3. Nutrition Department, Chinese PLA General Hospital, Beijing 100853, China |
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| Abstract: | In order to explore the hepatoprotective effect of peanut peptide(PP) on D-galactose(D-Gal)-induced liver damage in rats,fifty rats were randomly divided into five groups designated as control group,model group and three PP-treated groups.Except for the control group,the other groups were subcutaneously injected with D-Gal solution at a daily dosage of 400 mg/kg for 50 successive days to establish oxidative damage model.Meanwhile,rats in PP treatment groups were orally administered with PP at dosages of 200... |
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| Keywords: | peanut peptide liver damage D-galactose hepatoprotective effect |
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