| 制备乳脂肪球膜磷脂-维生素A脂质体的工艺优化 |
| |
| 引用本文： | 郭晨峰,张微,刘宁.制备乳脂肪球膜磷脂-维生素A脂质体的工艺优化[J].食品工业科技,2011,32(2):195-198. |
| |
| 作者姓名： | 郭晨峰 张微 刘宁 |
| |
| 作者单位： | 东北农业大学国家乳业工程技术中心,黑龙江哈尔滨150086;东北农业大学乳品科学教育部重点实验室,食品学院,黑龙江哈尔滨150030 |
| |
| 基金项目： | 国家863计划项目(2008AA10Z331); 黑龙江省“十一五”攻关课题(GB07B407) |
| |
| 摘 要： | 目的:制备可添加于婴儿液态配方乳的乳脂肪球膜磷脂-维生素A脂质体,并优化其制备参数。方法:本实验采用薄膜水合-高压均质法,应用乳脂肪球膜磷脂为膜材,制备维生素A脂质体,在单因素实验基础之上,探讨制备脂质体过程中磷脂浓度、主药与磷脂比例、胆固醇与磷脂比例、维生素E占磷脂百分比浓度、反应温度等制备因素对形成脂质体后包封率的影响规律。采用二次旋转正交组合实验方法设计实验,经SAS软件与Matlab软件处理数据得到配方原料指标和反应温度对脂质体包封率的影响。结果:优化得到制备脂质体工艺参数:磷脂浓度7.43%,磷脂与主药比例28.95∶1,磷脂与胆固醇比例为6.53∶1,维生素E占磷脂百分比浓度为0.83%,反应温度59.58℃,得到优化后最高包封率为88.77%,脂质体在扫描电子显微镜下观察,其超微结构为球状囊泡。结论:本实验首次以乳脂肪球膜磷脂作为膜材包埋维生素A制备脂质体,将传统的薄膜水合法与高压均质法相结合,成功制备出可添加于婴儿食品的可食性脂质体。
|
| 关 键 词： | 乳脂肪球膜磷脂 维生素A 薄膜水合-高压均质 脂质体 |
Optimization of technology for preparing vitamin A liposomes from milk fat globule membrane phospholipids |
| |
| GUo Chen-feng,ZHANG Wei,LIU Ning.Optimization of technology for preparing vitamin A liposomes from milk fat globule membrane phospholipids[J].Science and Technology of Food Industry,2011,32(2):195-198. |
| |
| Authors: | GUo Chen-feng ZHANG Wei LIU Ning |
| |
| Affiliation: | GUO Chen-feng1,2,ZHANG Wei 1,LIU Ning1,2 (1. Northeast Agricultural University,National Dairy Industry Engineering and Technique Center,Harbin 150086,China,2. Northeast Agricultural University,Key Laboratory of Dairy Science,Ministry of Education,College of Food Science,Harbin 150030,China) |
| |
| Abstract: | Objective:To produce the vitamin A(VitA)liposomes from milk fat globule membrane(MFGM)phospholipids which were added into infant liquid laboratory milk and optimize the parameter of the product. Methods:VitA liposomes MFGM was produced using the thin film hydration-high pressure homogenization method,and MFGM phosphatide as film material. Based on the single-factor experiment,the influencing rule of phosphatide concentration,the ratio between phosphatide concentration and principal agents,phosphatide concen... |
| |
| Keywords: | milk fat globule membrane phospholipids vitamin A thin film hydration-high pressure homogenization liposomes |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
