|
|||||
|
|
| 对氯苯丙酮的合成研究 | |
| 引用本文： | 王树清,张爱娟,王歆然.对氯苯丙酮的合成研究[J].精细石油化工进展,2012,13(4):37-39. |
| 作者姓名： | 王树清 张爱娟 王歆然 |
| 作者单位： | 1. 南通大学化学化工学院,南通,226019 2. 南通职业大学化工系,南通,226007 3. 南通惠康国际企业有限公司,南通,226009 |
| 基金项目： | 江苏省南通市科技局自然科学基金资助项目 |
| 摘 要： | 在催化剂存在下,以对氯苯甲酸和丙酸为原料合成对氯苯丙酮,考察了缩合反应温度、反应时间、原料配比和催化剂用量等条件对合成反应的影响,确定了最佳操作条件:缩合反应温度140℃,缩合反应时间8h,脱羧反应温度280℃,脱羧反应时间1.5h,n(丙酸)∶n(对氯苯甲酸)=0.45∶0.1,催化剂用量为2g(对氯苯甲酸用量为0.1 mol时).在此条件下,对氯苯丙酮的收率可达到85.68％以上,产品纯度达到99.0％以上. |
| 关 键 词： | 对氯苯丙酮 对氯苯甲酸 丙酸 合成 |
Research on p-Chloropropiophenone Synthesis |
|
| Wang Shuqing , Zhang Aijuan , Wang Xinran.Research on p-Chloropropiophenone Synthesis[J].Advances in Fine Petrochemicals,2012,13(4):37-39. | |
| Authors: | Wang Shuqing Zhang Aijuan Wang Xinran |
| Affiliation: | Wang Shuqing Zhang Aijuan Wang Xinran (1. College of Chemistry and Chemical Engineering of Nantong University, Nantong 226019; 2. Chemical Engineering Department, Nantong Vocational College, Nantong 226007 ; 3. Nantong Huikang International Enterprise Co. Ltd. , Nantong 226009) |
| Abstract: | p -Chloropropiophenone was synthesized with para- chlorobenzoic acid and propanoic acid as the materials in the presence of catalyst, and the effect of condensation reaction temperature, reaction time, ratio of materials and catalyst usage, etc. on the synthetic reaction. Optimum operation conditions were identi- fied： condensation reaction temperature is 140 ~C, condensation reaction time is 8 h, decarboxylation reaction temperature is 280 ~C, decarboxylation reaction time is 1.5 h, n （ propanoic acid） ： n （ para - chlorobenzoic acid） is 0.45： 0.1, and catalyst usage is 2 g when the usage of para - chlorobenzoic acid is 0.1 tool. The yield ofp -chloropropiophenone can be as high as 85.68% or more at such conditions with the purity of prod- uct higher than 99.0%. |
| Keywords: | p - chloropropiophenone para - chlorobenzoic acid propanoic acid synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |