Novel amino acid-based polymers for pharmaceutical applications |
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| Authors: | Viktória Torma Tamás Gyenes Zoltán Szakács Béla Noszál Árpád Némethy Miklós Zrínyi |
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| Affiliation: | 1.Department of Physical Chemistry and Material Sciences,Budapest University of Technology and Economics,Budapest,Hungary;2.E?tv?s Loránd University,Laboratory for Speciation, Drug and Trace Analysis, Institute of Chemistry,Budapest,Hungary;3.Hungarian Academy of Sciences,Department of Pharmaceutical Chemistry, Semmelweis University, Research Group for Drugs of Abuse and Doping Agents,Budapest,Hungary |
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| Abstract: | Summary Entirely amino acid-based polymers were prepared by side-chain attachment to polysuccinimide derived from the thermal polycondensation
of aspartic acid. Following deprotonation of various amino acid ester hydrochlorides by a secondary amine, the restored primary
amino groups initiated the ring-opening of succinimide to form amide bonds. 1H and 13C NMR measurements revealed that the mole fraction of the introduced amino acid side chains could be controlled by the reaction
time, while no hydrolysis of methyl ester groups was observed. The synthesized polymers contain exclusively amino acids, which
makes them promising candidates as base materials of controlled drug delivery systems. |
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