Cyanidin suppresses neoplastic cell transformation by directly targeting phosphatidylinositol 3-kinase |
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| Authors: | Nu Ry Song Hee Yang Jiman Park Jung Yeon Kwon Nam Joo Kang Yong Seok Heo Ki Won Lee Hyong Joo Lee |
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| Affiliation: | 1. World Class University Biomodulation Program, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-741, Republic of Korea;2. Food Science and Biotechnology Program, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-741, Republic of Korea;3. Advanced Institutes of Convergence Technology, Suwon 443-270, Republic of Korea;4. School of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea;5. Department of Chemistry, Konkuk University, Seoul 143-701, Republic of Korea |
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| Abstract: | Cyanidin, an anthocyanidin found in fruits and vegetables, has been reported to possess anti-cancer effects. However, there is no study on the chemopreventive effect of cyanidin against neoplastic cell transformation and its molecular mechanisms. In the present study, we compare the anti-carcinogenic effects of cyanidin and cyanidin-3-glucoside (C3G) and investigate their underlying mechanisms. The inhibitory effect of cyanidin on EGF-induced cell transformation was higher than those of C3G in JB6 P+ mouse epidermal (JB6 P+) cells. Both cyanidin and C3G showed dose-dependent radical scavenging activities. It is indicated that the divergent inhibitory effects of cyanidin and C3G are not due to their antioxidant activities. We found that cyanidin, but not C3G, inhibited the EGF-induced Akt/p70S6K phosphorylation. Moreover, cyanidin directly suppressed the activity of PI3K by binding to PI3K directly in an ATP-competitive manner, which indicates that PI3K is one of the molecular targets of cyanidin. |
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