| 铂黑/二茂铁修饰MEMS电极的葡萄糖传感器 |
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| 引用本文： | 姜利英,姚斐斐,陈青华,谢小品,崔光照. 铂黑/二茂铁修饰MEMS电极的葡萄糖传感器[J]. 微纳电子技术, 2010, 47(4). DOI: 10.3969/j.issn.1671-4776.2010.04.008 |
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| 作者姓名： | 姜利英 姚斐斐 陈青华 谢小品 崔光照 |
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| 作者单位： | 郑州轻工业学院电气信息工程学院,郑州,450002 |
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| 基金项目： | 河南省重点科技攻关资助项目(082102220015,092102310027);;郑州市科技攻关资助项目(083SGYG23143-6);;郑州轻工业学院博士科研基金资助项目(2007BSJJ002)n |
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| 摘 要： | 利用MEMS技术小批量加工了薄膜金电极。采用电化学沉积法在金电极表面修饰纳米铂黑颗粒,以有机功能性材料二茂铁作为电子媒介体,通过戊二醛-牛血清白蛋白共价交联固定葡萄糖氧化酶制得葡萄糖生物传感器。考察了不同修饰电极的电化学行为以及酶固定量和戊二醛浓度对传感器响应特性的影响。实验结果表明:该传感器响应时间仅为5s,在0.29V的低工作电压下,线性测量范围可达到0.5～22mmol/L,灵敏度为50.35μA/(cm2.mmol.L-1),相关系数为0.9925,差异系数为4.28%。
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| 关 键 词： | 葡萄糖 生物传感器 纳米铂黑 二茂铁 微电子机械系统 电化学沉积 |
Glucose Biosensors Based on MEMS Electrodes Modified by Pt Nanoparticles and Ferrocene |
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| Jiang Liying,Yao Feifei,Chen Qinghua,Xie Xiaopin,Cui Guangzhao. Glucose Biosensors Based on MEMS Electrodes Modified by Pt Nanoparticles and Ferrocene[J]. Micronanoelectronic Technology, 2010, 47(4). DOI: 10.3969/j.issn.1671-4776.2010.04.008 |
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| Authors: | Jiang Liying Yao Feifei Chen Qinghua Xie Xiaopin Cui Guangzhao |
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| Affiliation: | Institute of Electrical and Information Engineering;Zhengzhou University of Light Industry;Zhengzhou 450002;China |
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| Abstract: | Small amount of thin-film gold electrodes were fabricated with MEMS technology.Pt nanoparticles were prepared onto thin-film gold electrode using electrodeposition technique.Then glucose oxidases were immobilized by glutaraldehyde in the matrix of glutin and ferrocene on the former prepared electrode to detect the concentration of glucose.The electrochemical behavior of different modified electrodes was investigated,as well as the effect of glutaraldehyde concentration and the amount of enzyme immobilizatio... |
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| Keywords: | glucose biosensor nano platinum ferrocene MEMS electrochemical deposition |
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