| 11-氨基-3-氯-6,11-二氢-5,5-二氧代-6-甲基-二苯并[c,f][1,2]硫氮杂的合成 |
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| 引用本文： | 曹爽,张珩,杨艺虹,张秀兰,黄娇娇.11-氨基-3-氯-6,11-二氢-5,5-二氧代-6-甲基-二苯并[c,f][1,2]硫氮杂的合成[J].精细化工中间体,2010,40(2):26-29. |
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| 作者姓名： | 曹爽 张珩 杨艺虹 张秀兰 黄娇娇 |
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| 作者单位： | 武汉工程大学,绿色化工过程省部共建教育部重点实验室,湖北,武汉,430074 |
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| 摘 要： | 11-氨基-3-氯-6,11-二氢-5,5-二氧代-6-甲基-二苯并c,f]1,2]硫氮杂(1)是合成噻萘普汀的一个重要中间体。以4-氯-2-磺酰氯-苯甲酸甲酯和N-甲基苯胺为原料,经过缩合、水解、环合、还原、氯代和氨化共6步反应,得到产品1,总收率46.6%。1的结构经1HNMR,IR和MS确证。
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| 关 键 词： | 噻萘普汀 硫氮杂 环合 氯代 |
Synthesis of 11-Amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine |
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| CAO Shuang,ZHANG Heng,YANG Yi-hong,ZHANG Xiu-lan,HUANG Jiao-jiao.Synthesis of 11-Amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine[J].Fine Chemical Intermediates,2010,40(2):26-29. |
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| Authors: | CAO Shuang ZHANG Heng YANG Yi-hong ZHANG Xiu-lan HUANG Jiao-jiao |
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| Affiliation: | (Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China) |
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| Abstract: | 11 -Amino-3 -chloro-6,11 -dihydro-5,5 -dioxo-6-methyl-dibenzo c, f] 1,2 ] thiazepine （ 1 ） is a significant intermediate for the synthesis of Tianeptine. 1 was synthesized from methyl 4-chloro-2-（chlorosulfonyl） -benzoate and N-methyl aniline in six steps in an overall yield of 46.6%. The structure of the product was confirmed with IR, MS and ^ 1H NMR. |
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| Keywords: | tianeptine thiazepine cyclization chlorination |
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