响应面法优化谷氨酸亚铁的制备工艺

以氯化亚铁和谷氨酸钠为原料，在单因素试验的基础上，利用响应面分析法优化谷氨酸亚铁的固液相法制备工艺条件，选定介质pH值、反应温度和反应时间，通过中心组合试验，建立二次回归方程。结果表明，反应物物质的量比、介质pH值、反应时间及温度对反应产物产率均有一定的影响。优化的制备工艺条件为谷氨酸与Fe2＋物质的量比1∶1、介质pH 5.76、反应时间0.75 h、反应温度58.9 ℃，产率为77.79%。反应产物谷氨酸亚铁螯合物的组成为Fe(C5H7NO4)·2H2O。

Optimization of the Preparation Process of Ferrous Glutamate by Response Surface Methodology

Ferrous glutamate was prepared from ferrous chloride and sodium glutamate by a solid-liquid phase method.
The preparation process was optimized using combination of single factor method and response surface methodology. A
quadratic regression model indicating the effect of three variables including medium pH, reaction temperature and time on
ferrous glutamate yield was established using a central composite design. The results showed that the optimal conditions for
preparing ferrous glutamate were determined as follows: molar ratio of C5H9NO4 to Fe2+, 1:1; medium pH, 5.76; reaction
temperature, 58.9 ℃; and reaction time, 0.75 h. Under these conditions, the yield of ferrous glutamate was 77.79%. The
chemical formula of the ferrous glutamate was Fe(C5H7NO4)·2H2O.